骨質について
It is generally known that approximately 70 percent of bone strength is explained by bone mineral density, and the remaining 30 percent by "bone quality". Especially, in the monitoring of treatment, bone mineral density cannot fully explain the efficacy upon the risk of fracture. "Bone quality" has two aspects: structure property and material property. They are both influenced by bone turnover and have a relation to bone strength. From the viewpoint of diagnosis of osteoporosis, the factors of bone quality that can be clinically evaluated, are bone biomarkers as indices of bone remodeling, and structure property including bone geometry and trabecular microstructure. This article discusses the evaluation of bone quality and its clinical significance.
骨強度の70%は骨量でせつめいできる。残りの30%は骨質による寄与である。骨質は構造的側面と材質的側面がある。その両方が骨の新陳代謝に関係する。骨代謝新生の指標はこれらを反映しなければ意味がない。
Among several recent interests in bone quality, two topics will be stated. First, in vivo assessment of bone microstructure has been realized by the benefit of recent developments of imaging technique and technology, which is going to be applied to assess risk of fracture and efficacy of anti-osteoporotic agents. Second, in vitro analyses of nano-structure, including microcrack and cortical porosisty, contribute to assessment of bone material and biomechanical properties
2025年1月31日 | カテゴリー:骨粗鬆症 |