neprilysin/AI conference
does neprilysin expres on the monocyte by anything stimulating
Yes, neprilysin can be expressed on monocytes in response to various stimuli. Inflammatory signals, like cytokines and other molecules, can upregulate its expression on the surface of monocytes.
tell me what kind of cytekine stimulate monocytes
Several cytokines can stimulate monocytes. Key ones include interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. These cytokines play a crucial role in activating monocytes and modulating their functions, including the expression of molecules like neprilysin.
doesb il-1 stimulate mesangium
Yes, interleukin-1, particularly IL-1 beta, is known to stimulate mesangial cells. It can induce the proliferation and activation of these cells in the kidney, contributing to the progression of various kidney diseases.
il-1 can induce mesangium to make neprilysin
Yes, IL-1, especially IL-1 beta, can indeed induce mesangial cells to produce and express neprilysin. This is part of the inflammatory response in the kidneys, where mesangial cells can be activated to express various molecules, including neprilysin.
glucose-over load on paroximal tuble can express neprilysin
Yes, high glucose levels in the proximal tubules of the kidneys can lead to the expression of neprilysin. This is often seen in conditions like diabetes, where elevated glucose can affect the function of tubular cells, including the production of neprilysin.
ik-1 also induce it?
Yes, IL-1 can also induce the expression of neprilysin in various cells,
granule cell of macula densa can express neprilysin
The granular cells of the macula densa primarily function in the regulation of blood pressure and kidney function, rather than expressing neprilysin. Neprilysin is mainly expressed in other parts of the kidney, such as the proximal tubules and certain vascular structures, rather than the granular cells of the macula densa.
can free-neprilysin cut prorenin ito renin
Yes, free neprilysin can potentially cleave prorenin into renin. Neprilysin is a type of protease that can break down various peptides, and prorenin is one of its potential substrates, leading to the activation of the renin-angiotensin system.
where is exstraglomerular mesangium
The extraglomerular mesangium is located outside the glomerulus, near the juxtaglomerular apparatus. It's part of the juxtaglomerular complex and plays a role in regulating kidney blood flow and renin release.
which side of artery it is around
The extraglomerular mesangium is situated around the afferent arteriole, where it interacts with the macula densa cells and granular cells. This strategic location allows it to influence blood flow into the glomerulus and participate in blood pressure regulation.
afferent意味
Afferent bezieht sich auf etwas, das zu etwas hin führt. In Bezug auf Blutgefäße bedeutet es, dass ein Gefäß Blut zu einem bestimmten Organ oder Teil des Körpers leitet, wie die Afferentarteriole, die Blut zum Glomerulus bringt.
afferent 意味は
Afferent bezieht sich auf etwas, das zu etwas hinführt In Bezug auf Blutgefäße bedeutet es, dass ein Gefäß Blut zu einem bestimmten Organ oder Teil des Körpers leitet, wie die Afferentarteriole, die Blut zum Glomerulus bringt.
afferentの日本語の意味は
Afferent の 日本語 の 意味 は 求心 性 です 。 特定 の 方向 に 向かっ て 進む こと を 指し ます 。 血管 に つい て 言え ば 、 ある 器官 や 部位 に 向かう 血管 を 意味 し ます 。
輸入細動脈？
はい、そうです。 アフェレント 動脈 の 日本 語 訳 は 輸入 細動脈 です。 これは、 血液 を 腎臓 の 糸球体 に 運ぶ 血管 の こと を 指します。
葛根湯はIL-1を下げることが分かっているので、葛根湯は腎血流量を増やす？
葛根湯が IL-1 を 抑制 する こと が 知られて いる ことから、 それが 腎血流量 に 影響 を 与える 可能性 は 考えられます。 IL-1 の 抑制 により、 炎症 反応 が 軽減 され、 腎臓 の 血流 が 改善 される 可能性 が あります。 ただし、 葛根湯が 腎血流量 を 直接 どの程度 増加 させる かについては、 さらなる 研究が必要です。
how is menbrane binded neprilysin cut into free neprilysin
Membrane-bound neprilysin can be cleaved from the cell surface by enzymes called secretases. These enzymes cut the extracellular portion of neprilysin, releasing it from the membrane and allowing it to become free-soluble neprilysin in the surrounding fluids.
what is secretase?
Secretases are a type of protease that cleave proteins within the membrane. They are involved in processing various membrane proteins, including neprilysin, by cutting them to release soluble fragments or activate other functions.
how about CD26
CD26, also known as dipeptidyl peptidase 4 or DPP-4, is a membrane-bound protein with enzymatic activity. It can cleave certain peptides and play a role in various biological processes, including immune regulation and glucose metabolism.
secretase can cut CD26
Yes, secretases can also cleave CD26 from the cell surface. This process releases a soluble form of CD26 into the bloodstream, where it can still exert some of its functions, although its activity might differ from the membrane-bound form.
what cytokine induce secretase on what cell
Various cytokines can induce the expression of secretases on different cell types. For example, pro-inflammatory cytokines like IL-1 and TNF-alpha can stimulate the production of secretases in various cells, including immune cells and epithelial cells, influencing the processing of membrane proteins
EGF induce secretase
Yes, Epidermal Growth Factor (EGF) can induce the expression of secretases in certain cells. EGF is a growth factor that can stimulate cell proliferation and differentiation, and it can also affect the expression of enzymes involved in protein processing, like secretases.
is secretase on cell menbrane
Yes, many secretases are localized on the cell membrane, where they can process membrane-bound proteins. They are often embedded in the membrane, allowing them to interact with their substrates and cleave them at specific sites.
if so,egf-egf receptor complex transactivate secretase on cell surface
Yes, the binding of EGF to its receptor on the cell surface can activate various signaling pathways that lead to the transactivation of secretases. This means that the EGF-EGFR complex can promote the expression or activity of secretases, leading to the processing of membrane proteins.
how many are secretases reported
There are several different types of secretases reported, each with specific characteristics and functions. The main categories include alpha-, beta-, and gamma-secretases, which are involved in cleaving various membrane proteins, including those implicated in diseases like Alzheimer's disease.
2025年6月12日 | カテゴリー：循環器 |
